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1.
J Cardiothorac Surg ; 19(1): 231, 2024 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-38627781

RESUMO

BACKGROUND: Cardiac herniation occurs when there is a residual pericardial defect post thoracic surgery and is recognised as a rare but fatal complication. It confers a high mortality and requires immediate surgical correction upon recognition. We present a case of cardiac herniation occurring post thymectomy and left upper lobectomy. CASE PRESENTATION: Initial presentation: A 48-year-old male, hypertensive smoker presented with progressive breathlessness and was found to have a left upper zone mass confirmed on CT biopsy as carcinoid of unclear origin. PET-CT revealed avidity in a left anterior mediastinal area, left upper lobe (LUL) lung mass, mediastinal lymph nodes, and a right thymic satellite nodule. Intraoperatively: Access via left thoracotomy and sternotomy. The LUL tumour involved the left thymic lobe (LTL), left superior pulmonary vein (LSPV), left phrenic nerve and intervening mediastinal fat and pericardium, which were resected en-masse. The satellite nodule in the right thymic lobe (RTL) was adjacent to the junction between the left innominate vein and superior vena cava (SVC). The pericardium was resected from the SVC to the left atrial appendage. Clinical deterioration: Initially the patient was doing well clinically on day 1, however there was sudden bradycardia, hypotension, clamminess, and oligoanuria, with raised central venous pressures and troponins. ECG: no capture in leads V1-2, but positive deflections seen on posterior leads. Echo: no acoustic windows, but good windows seen posteriorly. CXR: left mediastinal shift. Redo operation: After initial resuscitation and stabilisation on the intensive care unit, on day 2 a redo-sternotomy revealed cardiac herniation into the left thoracic cavity with the left ventricular apex pointing towards the spine, and inferior caval kinking. After reduction and repair of the pericardial defect with a fenestrated GoreTex patch, the patient recovered well with complete resolution of the ECG and CXR. CONCLUSION: Cardiac herniation can even occur following sub-pneumonectomy lung resections and should be considered as a differential when faced with a sudden clinical deterioration, warranting early surgical correction.


Assuntos
Deterioração Clínica , Cardiopatias , Masculino , Humanos , Pessoa de Meia-Idade , Timectomia/efeitos adversos , Veia Cava Superior/cirurgia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Cardiopatias/cirurgia , Hérnia/etiologia , Hérnia/complicações , Pneumonectomia/efeitos adversos
2.
J Cardiothorac Surg ; 19(1): 153, 2024 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-38532449

RESUMO

BACKGROUND: The Cabrol procedure has undergone various modifications and developments since its invention. However, there is a notable gap in the literature regarding meta-analyses assessing it. METHODS: A systematic review and meta-analysis was conducted to evaluate the effectiveness and long-term outcomes of the Cabrol procedure and its modifications. Pooling was conducted using random effects model. Outcome events were reported as linearized occurrence rates (percentage per patient-year) with 95% confidence intervals. RESULTS: A total of 14 studies involving 833 patients (mean age: 50.8 years; 68.0% male) were included in this meta-analysis. The pooled all-cause early mortality was 9.0% (66 patients), and the combined rate of reoperation due to bleeding was 4.9% (17 patients). During the average 4.4-year follow-up (3,727.3 patient-years), the annual occurrence rates (linearized) for complications were as follows: 3.63% (2.79-4.73) for late mortality, 0.64% (0.35-1.16) for aortic root reoperation, 0.57% (0.25-1.31) for hemorrhage events, 0.66% (0.16-2.74) for thromboembolism, 0.60% (0.29-1.26) for endocarditis, 2.32% (1.04-5.16) for major valve-related adverse events, and 0.58% (0.34-1.00) for Cabrol-related coronary graft complications. CONCLUSION: This systematic review provides evidence that the outcomes of the Cabrol procedure and its modifications are acceptable in terms of mortality, reoperation, anticoagulation, and valve-related complications, especially in Cabrol-related coronary graft complications. Notably, the majority of Cabrol procedures were performed in reoperations and complex cases. Furthermore, the design and anastomosis of the Dacron interposition graft for coronary reimplantation, considering natural anatomy and physiological hemodynamics, may promise future advancements in this field.


Assuntos
Cardiopatias , Próteses Valvulares Cardíacas , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Prótese Vascular , Valva Aórtica/cirurgia , Aorta/cirurgia , Reoperação , Cardiopatias/cirurgia
3.
Clin Genitourin Cancer ; 22(2): 599-609.e2, 2024 04.
Artigo em Inglês | MEDLINE | ID: mdl-38369388

RESUMO

INTRODUCTION: We aimed to assess the association between comorbidities and prostate cancer management. PATIENTS AND METHODS: We studied 12,603 South Australian men diagnosed with prostate cancer between 2003 and 2019. Comorbidity was measured one year prior to prostate cancer diagnosis using a medication-based comorbidity index (Rx-Risk). Binomial logistic regression analyses were used to assess the association between comorbidities and primary treatment selection (active surveillance, radical prostatectomy (RP), external beam radiotherapy (EBRT) with or without androgen deprivation therapy (ADT), brachytherapy, ADT alone, and watchful waiting (WW)). Certain common comorbidities within Rx-Risk (cardiac disorders, diabetes, chronic airway diseases, depression and anxiety, thrombosis, and chronic pain) were also assessed. All models were adjusted for sociodemographic and tumor characteristics. RESULTS: Likelihood of receiving RP was lower among men with Rx-Risk score ≥3 (odds ratio (OR) 0.62, 95%CI:0.56-0.69) and Rx-Risk 2 (OR 0.80, 95%CI:0.70-0.92) compared with no comorbidity (Rx-Risk ≤0). Men with high comorbidity (Rx-Risk ≥3) were more likely to have received ADT alone (OR 1.76, 95%CI:1.40-2.21), EBRT (OR 1.30, 95%CI:1.17-1.45) or WW (OR 1.49, 95%CI:1.19-1.88) compared with Rx-Risk ≤0. Pre-existing cardiac and respiratory disorders, thrombosis, diabetes, depression and anxiety, and chronic pain were associated with lower likelihood of selecting RP and higher likelihood of EBRT (except chronic airway disease) or WW (except diabetes and depression and anxiety). Cardiac disorders and thrombosis were associated with higher likelihood of selecting ADT alone. Furthermore, age had greater effect on treatment choice than the level of comorbidity. CONCLUSION: High comorbidity burden was associated with primary treatment choice, with significantly less RP and more EBRT, WW and ADT alone among men with higher levels of comorbidity. Each of the individual comorbid conditions also influenced treatment selection.


Assuntos
Braquiterapia , Dor Crônica , Diabetes Mellitus , Cardiopatias , Neoplasias da Próstata , Trombose , Masculino , Humanos , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/epidemiologia , Antagonistas de Androgênios/uso terapêutico , Dor Crônica/cirurgia , Austrália/epidemiologia , Comorbidade , Prostatectomia , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/cirurgia , Cardiopatias/cirurgia , Trombose/cirurgia
4.
Transfus Clin Biol ; 31(1): 19-25, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38029957

RESUMO

BACKGROUND: Cell-derived microparticles (MPs) are membrane vesicles that have emerged as a potential biomarker for various diseases and their clinical complications. This study investigates the role of MPs as a risk factor for blood transfusion in patients with valve heart disease undergoing cardiac surgery. METHODS: Forty adult patients undergoing heart valve surgery with cardiopulmonary bypass (CPB) were enrolled, and venous blood samples were collected prior to surgical incision. Plasma rich in MPs was prepared by double centrifugation, and the concentration of MPs was determined using the Bradford method. Flow cytometry analysis was performed to determine MPs count and phenotype. Patients were divided into "with transfusion" (n = 18) and "without transfusion" (n = 22) groups based on red blood cell (RBC) transfusion. RESULTS: There was no significant difference in MPs concentration between the "with transfusion" and "without transfusion" groups. Although the count of preoperative platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs), and red cell-derived MPs (RMPs) was higher in "without transfusion" group, these differences were not statistically significant. The preoperative PMPs count was negatively correlated with RBC transfusion (P = 0.005, r = -0.65). Multivariate logistic regression analysis revealed that the count of CD41+ PMPs, Hemoglobin (Hb), and RBC count were risk factors for RBC transfusion. CONCLUSION: This study suggests that the presurgical levels of PMPs, Hb, and RBC count can serve as risk factors of RBC transfusion in patients with valve heart disease undergoing cardiac surgery. The findings provide insights into the potential use of MPs as biomarkers for blood transfusion prediction in cardiac surgery.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Micropartículas Derivadas de Células , Cardiopatias , Adulto , Humanos , Transfusão de Sangue/métodos , Hemoglobinas , Fatores de Risco , Cardiopatias/etiologia , Cardiopatias/cirurgia
5.
Pediatr Transplant ; 28(1): e14682, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38149311

RESUMO

BACKGROUND: A serial multiple mediator analysis was conducted to test the predictive effects of heart disease symptoms on pediatric heart transplant recipients health-related quality of life (HRQOL) from their perspective with patient-perceived cognitive problems, patient health communication, and treatment anxiety as hypothesized mediators. METHODS: One hundred and nineteen pediatric heart transplant recipients aged 8-18 completed the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL Cardiac Module Heart Disease Symptoms Scale, Cognitive Problems Scale, Communication Scale and Treatment Anxiety Scale. The serial multiple mediator analysis tested the hypothesized sequential mediation of the cross-sectional association between patient-perceived heart disease symptoms and their perceived HRQOL. RESULTS: Heart disease symptoms indirect effects on HRQOL were sequentially mediated through cognitive problems, with cognitive problems' indirect effects mediated through patient health communication and treatment anxiety. A predictive analytics analysis consisting of age, gender, and time since transplant demographic covariates, demonstrated that heart disease symptoms, cognitive problems, patient health communication, and treatment anxiety accounted for 66 percent of the variance in patient-perceived HRQOL (p < .001), representing a large effect size. CONCLUSIONS: Patient-perceived heart disease symptoms indirect effects on HRQOL in pediatric heart transplant recipients was explained by patient-perceived cognitive problems, patient health communication, and treatment anxiety. Delineating heart disease symptoms indirect effects on HRQOL from the perspective of pediatric patients may inform targeted clinical interventions to improve daily functioning in pediatric heart transplant recipients.


Assuntos
Doença da Artéria Coronariana , Cardiopatias , Transplante de Coração , Humanos , Criança , Qualidade de Vida/psicologia , Estudos Transversais , Cardiopatias/complicações , Cardiopatias/cirurgia , Ansiedade
6.
G Ital Cardiol (Rome) ; 25(1): 57-59, 2024 Jan.
Artigo em Italiano | MEDLINE | ID: mdl-38140999

RESUMO

Atrio-esophageal fistula (AEF) is a rare (0.02-0.1%) complication of radiofrequency ablation for atrial fibrillation and is associated with high mortality. It typically presents between 2 and 6 weeks after catheter ablation. AEF was reported to be the second complication as cause of death after radiofrequency ablation with a mortality rate of 71%. Common clinical features of AEF include dysphagia, nausea, heartburn, hematemesis or melena, high fever, sepsis, pericardial or pleural effusions, mediastinitis, seizures, and stroke. Once the diagnosis of AEF is made, early surgical repair is mandatory. Herein, we report a case of a AEF treated surgically without extracorporeal circulation.


Assuntos
Fibrilação Atrial , Ablação por Cateter , Fístula Esofágica , Cardiopatias , Humanos , Fibrilação Atrial/complicações , Átrios do Coração/cirurgia , Fístula Esofágica/etiologia , Fístula Esofágica/cirurgia , Fístula Esofágica/diagnóstico , Cardiopatias/etiologia , Cardiopatias/cirurgia , Cardiopatias/diagnóstico , Ablação por Cateter/efeitos adversos
7.
BMJ Case Rep ; 16(12)2023 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-38087486

RESUMO

A woman in her 60s was brought to the previous hospital with respiratory distress. She was referred for the treatment of severe cardiac dysfunction and a mobile mass in the left ventricle. Echocardiography revealed the mass to be of 20×11 mm in size, mobile and slightly attached to the left ventricle by a stalk. As MRI had already revealed a small cerebral infarction, we have decided to perform emergency thrombectomy of the left ventricle. As the left ventricular contractility was diffusely impaired, we were able to remove the mass without any residuals using a transseptal approach without a left ventricular incision using a three-dimensional microscope system. The pathological diagnosis of the mass was thrombus, and subsequent close examination led to the diagnosis of cardiac sarcoidosis. We report the surgical technique and removal of a left ventricular thrombus complicated by cardiac sarcoidosis.


Assuntos
Cardiopatias , Miocardite , Sarcoidose , Trombose , Feminino , Humanos , Cardiopatias/complicações , Cardiopatias/diagnóstico por imagem , Cardiopatias/cirurgia , Miocardite/complicações , Sarcoidose/complicações , Sarcoidose/diagnóstico , Trombectomia/métodos , Trombose/complicações , Trombose/diagnóstico por imagem , Trombose/cirurgia , Pessoa de Meia-Idade , Idoso
8.
Kyobu Geka ; 76(13): 1131-1134, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38088079

RESUMO

A rare case of isolated right atrial thrombus under anticoagulant therapy for atrial fibrillation is reported herein. The patient was an 81-year-old man undergoing anticoagulant therapy with oral warfarin for atrial fibrillation. During preoperative screening for eye surgery, echocardiography revealed a mobile mass in the right atrium, and emergency hospital admission was indicated. Excision of the right atrial thrombus was performed, and no residual thrombus was detected on postoperative imaging studies. This case was considered a good indication for surgical resection because of potential risk of fatal embolism.


Assuntos
Fibrilação Atrial , Cardiopatias , Trombose , Masculino , Humanos , Idoso de 80 Anos ou mais , Fibrilação Atrial/complicações , Fibrilação Atrial/tratamento farmacológico , Fibrilação Atrial/cirurgia , Cardiopatias/diagnóstico por imagem , Cardiopatias/cirurgia , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/cirurgia , Trombose/diagnóstico por imagem , Trombose/tratamento farmacológico , Trombose/cirurgia , Anticoagulantes/efeitos adversos
9.
Kyobu Geka ; 76(13): 1136-1139, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38088080

RESUMO

We report a very rare case of giant pericardial cyst with left ventricular compression on echocardiography. A 61-year-old man visited our hospital with a feeling of chest tightness. A cardiologist ruled out cardiac diseases of the patients and he was referred to us for examination and treatment of an abnormal left lung field shadow on chest x-ray. Chest computed tomography (CT) showed a 16×7.5 cm cystic mass in connect with the heart and diaphragm. Echocardiography showed that the cystic mass was compressing the left ventricle. Surgical resection was attempted by video-assisted thoracoscopic surgery (VATS). We aspirated serous liquid contents in the cyst and partially resected the cyst wall excepting cardiac side. After confirming the cyst was not a pericardial diverticulum, we completely resected its residual wall. His postoperative course was uncomplicated. The cyst was pathologically diagnosed as a pericardial cyst.


Assuntos
Cardiopatias , Cisto Mediastínico , Masculino , Humanos , Pessoa de Meia-Idade , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/cirurgia , Cisto Mediastínico/complicações , Cisto Mediastínico/diagnóstico por imagem , Cisto Mediastínico/cirurgia , Cirurgia Torácica Vídeoassistida , Tomografia Computadorizada por Raios X , Ecocardiografia , Cardiopatias/complicações , Cardiopatias/diagnóstico por imagem , Cardiopatias/cirurgia
10.
An. sist. sanit. Navar ; 46(3)sept. - dic. 2023. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-230029

RESUMO

Fundamento. Las masas y quistes cardíacos son entidades bien conocidas, cuya reducida prevalencia y sintomatología inespe-cífica dificultan su diagnóstico. El objetivo del estudio fue ca-racterizar el cuadro de los pacientes afectos en nuestro medio para orientar futuros diagnósticos.Metodología. Estudio descriptivo de los pacientes intervenidos de tumores y quistes cardíacos entre 2002 y 2022 mediante la búsqueda en el registro del Servicio de Cardiología y Cirugía Cardíaca de la Clínica Universidad de Navarra (Pamplona, Es-paña). Se recogieron variables sociodemográficas, clínicas, his-tológicas y quirúrgicas.Resultados. Se identificaron 13 pacientes, la mayoría (76,92%) mujeres, con media de edad 63,08 años (DE: 15,17). El 92,31% de los pacientes tenían al menos un factor de riesgo cardiovascular, siendo los más prevalentes un IMC ≥25 kg/m2 y la hipertensión arterial (61,54% y 53,85%, respectivamente). El tipo de masa car-díaca más frecuente fue el mixoma (69,23%). El 46,15% de masas cardiacas fueron hallazgos incidentales; el síntoma más frecuen-te fue la disnea (53,85%) y el 30,77% de los pacientes se encontra-ban asintomáticos. . La prueba de imagen más empleada para en el diagnóstico fue la ecocardiografía transtorácica Doppler color (69,23%). La concordancia entre los diámetros medios precirugía y postcirugía resultó muy alta (CCI = 0,807, IC95%: 0,450-0,943).Conclusiones. Se describieron los cuadros de los pacientes, apor-tando información poco descrita en la literatura, como los facto-res de riesgo cardiovascular más frecuentes en estas entidades. Se describieron un caso de leiomiosarcoma cardíaco y un caso de sarcoma intimal del tronco pulmonar, dos tipos de tumores extremadamente raros de los que existen pocos casos descritos (AU)


Background. Masses and cysts in the heart are well-known entities, but their low prevalence and non-specific symptoms makes the diagnosis difficult. We aimed to characterize the fea-tures of these entities in our environment.Methods. We carried out a search of patients who underwent surgery for tumors and cysts in the heart between 2002 and 2022 in the registry of the Department of Cardiology and Car-diac Surgery of Clínica Universidad de Navarra (Pamplona, Spain). Sociodemographic, clinical, histological, and surgical variables were collected.Results. We identified 13 patients; mean age was 63.08 ± 15.17 years, 76.92% were female and 92.31% had at least one car-diovascular risk factor, e.g., BMI ≥ 25 kg/m2 and high blood pressure (61.54% and 53.85%, respectively). The most com-mon type of cardiac tumors were myxomas (69.23%). Around half (46.15%) were incidental; the most frequent symptom was dyspnea (53.85%); 30.77% of the patients were asymptomatic. The most commonly used imaging technique for the diagno-sis was transthoracic Doppler echocardiography (69.23%). The agreement between the mean diameters before and after sur-gery was very high (ICC = 0.807, 95%CI: 0.450-0.943).Conclusions. We describe the features of masses and cysts in the heart (77% female patients) and provide information scarcely available in the literature, e.g., the most frequent car-diovascular risk factors for this population. A case of cardiac leiomyosarcoma and a case of intimal sarcoma of the pulmo-nary trunk are described, two extremely rare tumors for which there are few described cases (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Cardiopatias/diagnóstico , Cardiopatias/cirurgia , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Estudos Retrospectivos , Hospitais Gerais , Espanha
11.
Catheter Cardiovasc Interv ; 102(6): 1105-1108, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37855191

RESUMO

Intracardiac masses and specifically right atrial thrombi can be difficult to manage and carry a high mortality rate. Typically, surgical removal or mechanical thrombectomy can be performed though may not be suitable for all patients. We present a unique case of a sickle cell patient with a large pedunculated right atrial thrombus that was successfully extracted using the novel ONO Retrieval Device.


Assuntos
Fibrilação Atrial , Cardiopatias , Trombose , Humanos , Trombectomia , Cardiopatias/diagnóstico por imagem , Cardiopatias/cirurgia , Resultado do Tratamento , Trombose/diagnóstico por imagem , Trombose/etiologia , Trombose/cirurgia
12.
J Cardiovasc Electrophysiol ; 34(11): 2403-2405, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37787011

RESUMO

INTRODUCTION: Intracardiac echocardiography (ICE) reveals mobile thrombus on implantable electronic device leads in some patients undergoing electrophysiologic procedures. METHODS: ICE was performed in a patient undergoing ventricular tachycardia (VT) ablation. RESULTS: ICE showed extensive mobile thrombi on the implantable cardioverter defibrillator lead. Radiofrequency catheter ablation of VT from perimitral scar was safely performed via a retrograde aortic approach. After the procedure, chronic anticoagulation was initiated. CT-angiography of the chest 2 months later showed no pulmonary emboli. CONCLUSIONS: The significance of these thrombi, as related to chronic pulmonary embolization, warrants further study.


Assuntos
Ablação por Cateter , Cardiopatias , Taquicardia Ventricular , Trombose , Humanos , Taquicardia Ventricular/diagnóstico por imagem , Taquicardia Ventricular/cirurgia , Vento , Cardiopatias/cirurgia , Trombose/diagnóstico por imagem , Trombose/etiologia , Ablação por Cateter/métodos , Cabelo , Resultado do Tratamento
13.
J Bone Joint Surg Am ; 105(23): 1867-1874, 2023 12 06.
Artigo em Inglês | MEDLINE | ID: mdl-37733907

RESUMO

BACKGROUND: There are little long-term health data, particularly in terms of body composition and development of metabolic syndromes, to help surgeons to guide the decision between limb salvage and amputation in patients with limb-threatening trauma. The purpose of this study was to compare long-term health outcomes after high-energy lower-extremity trauma between patients who underwent attempted flap-based limb salvage or amputation. METHODS: We performed a retrospective review of servicemembers with a minimum 10-year follow-up who underwent flap-based limb salvage followed by unilateral amputation or continued limb salvage after combat-related, lower-extremity trauma between 2005 and 2011. Patient demographic characteristics, injury characteristics, and health outcomes including body mass index (BMI) and development of metabolic disease (e.g., hyperlipidemia, hypertension, heart disease, and diabetes) were compared between treatment cohorts. Adjusted BMIs were calculated for the amputation cohort to account for lost surface area. We performed multivariable and propensity score analysis to determine the likelihood of developing obesity or metabolic disease. RESULTS: In this study, 110 patients had available long-term follow-up (mean, 12.2 years) from the time of the injury. Fifty-six patients underwent limb salvage and 54 patients underwent unilateral amputation. There was no difference in preinjury BMI (p = 0.30). After adjusting for limb loss, the amputation cohort had a trend toward higher BMIs at ≥1 years after the injury, a higher rate of obesity, and a greater increase in BMI from baseline after the injury. The development of metabolic comorbidities was common after both amputation (23 [43%] of 54) and limb salvage (27 [48%] of 56). With the numbers available, we were unable to demonstrate a difference in risk for the development of hypertension, hyperlipidemia, diabetes, heart disease, or any comorbidity other than obesity (p > 0.05). CONCLUSIONS: Amputations may be medically necessary and may decrease pain, improve mobility, and/or expedite return to activity compared with limb salvage after similar injuries. However, limb loss may negatively impact metabolic regulation and may contribute to a higher risk of obesity despite beneficial effects on mobility. LEVEL OF EVIDENCE: Therapeutic Level III . See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Diabetes Mellitus , Cardiopatias , Hiperlipidemias , Hipertensão , Traumatismos da Perna , Doenças Metabólicas , Humanos , Salvamento de Membro , Resultado do Tratamento , Traumatismos da Perna/cirurgia , Amputação Cirúrgica , Estudos Retrospectivos , Diabetes Mellitus/cirurgia , Obesidade , Cardiopatias/cirurgia , Hiperlipidemias/cirurgia , Hipertensão/cirurgia
15.
BMJ Open ; 13(7): e072293, 2023 07 18.
Artigo em Inglês | MEDLINE | ID: mdl-37463807

RESUMO

INTRODUCTION: Continually rising life expectancy and a shift towards an ageing population are resulting in an increasing population of nonagenarians. By 2030, the global population of nonagenarians is expected to exceed 30 million. The incidence of symptomatic cardiac disease is reported to occur in 25% of those aged over 75 years. Therefore, the number of nonagenarians undergoing cardiac surgery is also expected to increase. A linear relationship between advanced age and surgical risk has previously been demonstrated; however, it is not yet known whether this knowledge extends to the perioperative course and mortality of nonagenarians undergoing cardiac surgery. This scoping review aims to review the literature, assess whether a deficiency exists in the published literature and potentially identify knowledge gaps to guide future efforts to improve the understanding of nonagenarians undergoing cardiac surgery. METHODS AND ANALYSIS: Following the relevant aspects of the Preferred Reporting Items for Systematic Review and Meta-Analysis Extension for Scoping Review guidelines, electronic databases of MEDLINE, EMBASE and the Cochrane Library will be systematically searched, with additional reference tracking of eligible studies. Studies reporting the outcomes of nonagenarians undergoing open cardiac surgery or minimally invasive cardiac surgery requiring cardiopulmonary bypass will be included. Screening and data extraction will be performed by two reviewers independently. The data will be analysed and summarised descriptively with a narrative approach. Qualitative data that capture quality-of-life outcomes will be subjected to thematic analysis where feasible. Additionally, reporting results will highlight similarities and differences in nonagenarian selection for surgery. ETHICS AND DISSEMINATION: Ethics approval was not required. The findings will be disseminated through professional networks, conference presentations and publications in scientific journals.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Cardiopatias , Idoso de 80 Anos ou mais , Humanos , Idoso , Nonagenários , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Cardiopatias/epidemiologia , Cardiopatias/cirurgia , Qualidade de Vida , Procedimentos Cirúrgicos Minimamente Invasivos , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Metanálise como Assunto
16.
Cardiol Young ; 33(11): 2443-2445, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37489509

RESUMO

Cardiac mass in children is rare and insidious onset, and primary cardiac mass is less than secondary mass. Among the malignant tumours in children with tumour thrombus in the venous system, about 98% of the cases are nephroblastoma. But it is still rare for the tumour thrombus to reach the level of the atrium or even enter the right ventricle. In this case, the child complained of chest tightness and palpitation and went to the doctor and found Wilms tumour complicated with intracardiac tumour thrombus.


Assuntos
Cardiopatias , Neoplasias Cardíacas , Neoplasias Renais , Trombose , Tumor de Wilms , Criança , Humanos , Neoplasias Renais/complicações , Neoplasias Renais/cirurgia , Neoplasias Renais/patologia , Tumor de Wilms/complicações , Tumor de Wilms/cirurgia , Tumor de Wilms/patologia , Trombose/diagnóstico por imagem , Trombose/cirurgia , Trombose/etiologia , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/diagnóstico por imagem , Cardiopatias/diagnóstico , Cardiopatias/cirurgia , Cardiopatias/complicações
17.
Medicina (Kaunas) ; 59(6)2023 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-37374307

RESUMO

Background and Objectives: Pulmonary hypertension (PH) secondary to left-sided valvular heart disease is associated with poor cardiac surgical outcome compared with patients without PH. Our objective was to investigate the prognostic factors of surgical outcome in patients with PH undergoing mitral valve (MV) and tricuspid valve (TV) surgery, in order to risk stratify their management. Materials and Methods: This is a retrospective observational study on patients with PH who underwent MV and TV surgery from 2011 to 2019. The primary outcome was all-cause mortality. The secondary outcomes were post-op respiratory and renal complications, length of intensive care unit stay and length of hospital stay. Results: Seventy-six patients were included in this study. The all-cause mortality was 13% (n = 10), with mean survival of 92.6 months. Among the patients, 9.2% (n = 7) had post-op renal failure requiring renal replacement therapy and 6.6% (n = 5) had post-op respiratory failure requiring intubation. Univariate analysis demonstrated that pre-operative left ventricular ejection fraction (LVEF), peak systolic tissue velocity at the tricuspid annulus (S') and etiology of MV disease were associated with respiratory and renal failure. Tricuspid annular plane systolic excursion (TAPSE) was associated with respiratory failure only. S', type of operation, LVEF, urgency of surgery, and etiology of MV disease were found to be predictive of mortality. After excluding redo mitral surgery, all statistically significant findings remain unchanged, with the addition of right ventricular (RV) size being associated with respiratory failure. In the subgroup analysis of routine cases (n = 56), patients with primary mitral regurgitation who underwent mitral valve repair had better survival outcome. Conclusions: Urgency of surgery, etiology of MV disease, type of operation (replacement or repair), S' and pre-op LVEF are prognostic indicators in this small cohort of patients with PH undergoing MV and TV surgery. A larger prospective study is warranted to validate our findings.


Assuntos
Cardiopatias , Hipertensão Pulmonar , Valva Mitral , Valva Tricúspide , Humanos , Hipertensão Pulmonar/complicações , Valva Tricúspide/cirurgia , Valva Mitral/cirurgia , Cardiopatias/cirurgia , Estudos Retrospectivos , Tempo de Internação , Mortalidade , Função Ventricular Esquerda , Resultado do Tratamento , Ecocardiografia , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Análise de Sobrevida , Insuficiência Renal/complicações , Doenças Respiratórias/complicações
18.
Am J Cardiol ; 201: 185-192, 2023 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-37385173

RESUMO

Endocardial-epicardial (Endo-epi) catheter ablation (CA) has been shown to reduce the rate of ventricular arrhythmia (VA) ablation in patients with structural heart disease (SHD). However, the effectiveness of this technique compared with endocardial (Endo) CA alone remains uncertain. This meta-analysis aims to compare the effectiveness of Endo-epi versus Endo alone in reducing the risk of VA recurrence in patients with SHD. We searched PubMed, Embase, and Cochrane Central Register with a comprehensive strategy. We used reconstructed time-to-event data to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for VA recurrence accompanied by at least one Kaplan-Meier curve for ventricular tachycardia recurrence. Our meta-analysis included 11 studies with a total of 977 patients. Endo-epi had a significantly lower risk of VA recurrence compared with those treated with Endo alone (HR 0.43, 95% CI 0.32 to 0.57, p <0.001). Subgroup analysis based on the type of cardiomyopathy revealed that patients with arrhythmogenic right ventricular cardiomyopathy and ischemic cardiomyopathy (ICM) benefited significantly from Endo-epi in reducing the risk of VA recurrence (HR 0.835, 0.55 to 0.87, p <0.021). However, there was no significant difference with non-ICM (HR 0.440, 0.55 to 0.87, p <0.33). The analysis of conditional survival showed that patients who remained free of VA recurrence for 5 years after the procedure had a very low probability of developing VA recurrence thereafter. In conclusion, Endo-epi CA is more effective than Endo CA alone in reducing the risk of VA recurrence in patients with SHD, especially those with arrhythmogenic right ventricular cardiomyopathy and ICM.


Assuntos
Displasia Arritmogênica Ventricular Direita , Cardiomiopatias , Ablação por Cateter , Cardiopatias , Taquicardia Ventricular , Humanos , Displasia Arritmogênica Ventricular Direita/complicações , Displasia Arritmogênica Ventricular Direita/cirurgia , Resultado do Tratamento , Cardiopatias/complicações , Cardiopatias/cirurgia , Cardiomiopatias/etiologia , Ablação por Cateter/métodos , Recidiva
19.
J Extra Corpor Technol ; 55(2): 82-85, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37378440

RESUMO

Intracardiac thrombi such as pulmonary emboli represent a high risk of mortality. In this case study, we review two cases of intracardiac thrombi occurring within 24 h of one another and managed differently by the same cardiothoracic surgical team, highlighting the importance of an individualized approach as well as an understanding of current guidelines and contemporary management techniques.


Assuntos
Cardiopatias , Embolia Pulmonar , Trombose , Humanos , Trombose/cirurgia , Cardiopatias/cirurgia
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